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Published: 24 Jun 2022 851 views
This project will apply biostatistical analysis to RNAseq data to undercover novel roles for microglia and astrocytes in brain injury occurring in preterm born infants.
Permanent brain injury in babies can result from exposure to an inflammatory insult combined with being born preterm (<37 of 40 weeks’ gestation). Over their lifetime, these infants frequently struggle in academic and social settings due to cognitive and social deficits linked to their brain injuries. It is known that the cellular reactivity, termed the tertiary phase of injury persists into childhood and adolescence after early brain injury and is also observed after multiple other forms of brain injury. These changes involve dysfunction of astrocytes and microglia and they sensitise the brain to further injury. By identifying these changes creates opportunities for novel therapeutic development. This project will add to this field of research by identifying the signature of injury in a mouse model of preterm inflammatory brain injury.
| Application Deadline | 01 Jul 2023 |
| Type | Postgraduate |
| Sponsor | RMIT University |
| Gender | Men and Women |
Project attached to a NHMRC funded grant, normal RMIT PhD Scholarship terms and conditions.
Standard RMIT conditions including English requirements, and either a Honours degree with a H1 grade, or equivalent industry or academic experience. Please get in touch to discuss.
Please email [email protected] to discuss the project.
For more details, visit RMIT University website.